Being ‘fully vaccinated’ but not amplified does not deter Omicron

Two shots of the COVID-19 vaccine without an additional booster offer no lasting protection against Omicron infection, and coronavirus infection is just as effective as a new booster shot in preventing a new disease caused by Omicron, researchers reported on Wednesday.

At the same time, any resistance to the more contagious variant, from infection or vaccination, appear to offer significant and lasting protection against serious illness, hospitalization and death, the researchers found. And if you haven’t gotten the virus or the vaccine yet, doctors urge, it’s better to get the jab.

tea resultpublished in the New England Journal of Medicine, provides some of the best understanding to date about the longevity of different strains of coronavirus resistance and offers insights into the future of pandemic.

“COVID-19 will stay with us forever. It will never go away. But the question is: Can we survive it in some way?” Laith Jamal Abu-Raddad, an epidemiologist of infectious disease at Weill Cornell Medicine-Qatar and co-author of the study. “And the first results we got were really very encouraging.”

The study is the latest of several examining nationwide data from Qatar, the small Middle East country of less than 3 million people.

Qatar’s population is much younger than most developed countries – only 9% of its residents are older than 50, compared to about 35% in the U.S. It’s also more diverse, as 89% of its residents are expatriates from 150 other countries. The country also has a robust coronavirus testing program, a high absorption COVID-19 vaccine and a centralized public health database that provides researchers with clean, clear data. to analyze the effects of vaccines over time.

For this latest study, the researchers looked at the data as Omicron subvariants known as BA.1 and BA.2 devastated the country’s population from late December to late February.

They found that people who received two shots of the Comirnaty vaccine from Pfizer and BioNTech or the Spikevax shot from Moderna when they first applied but then did not pay attention to strengthening their immune systems with booster shots have no protection against mild to moderate. case of COVID-19. Six months after their last shooting, they were as easily taken with a positive test and pain symptoms as anyone – but still showed strong resistance to severe pain.

Prior infection is about 46% effective in preventing a symptomatic infection. when fully vaccinated and raised about 52% effective. And having natural resistance from a previous infection as well as resistance from a vaccine and booster was the most effective of all, reducing the risk of COVID-19 by 77%.

The numbers represent a sharp decrease from the first days of vaccines, when clinical trials show that they are 94% to 95% effective in preventing even mild diseases. But as the coronavirus accumulates mutations, vaccines have become less effective at identifying the virus and preventing infections.

“Immune evasion is much higher” with Omicron, Abu-Raddad said. It’s “actually a new virus.”

The passage of time since the last increase in resistance from infection or a shot also impairs the body’s resistance to the type of infection that gets noticeable symptoms and a second pink home test line.

“However,” Raddad said, “and I think this is really the important part: Resistance against severe COVID-19 is really preserved.”

It may seem like a past infection is just as useful as an Omicron anti -vaccine vaccine, but doctors have a vague preference: Get the shot, not the virus.

“It’s definitely a lot, much safer to be vaccinated than to be infected,” he said Dr. Jeffrey Klausneran infectious disease specialist at the Keck School of Medicine at USC.

“The vaccine only presents a small piece of the virus,” Klausner said. “The whole virus, if you are infected, spreads throughout the body, it will cause different symptoms in different parts of the body and increase your risk of high COVID or a long duration of illness.”

Previous studies documented at Omicron’s shocking ability to avoid existing vaccine antibodies.

Data from the Qatar group adds to that work by shedding light on the longevity of resistance, as Robert “Chip” Schooley, an infectious disease specialist at UC San Diego. “They’ve done a much better job of understanding decay in response to resistance over time than we have” in the U.S., he said.

“Getting COVID now – if you’re vaccinated and you’re in good health – is more troublesome than it is a life -threatening event for most people,” Schooley said. “It’s a very different disease from two years ago, when we had a largely non -immune human population, and a virus that came to you for the first time.

“Now we have a virus that most of us detect through vaccination, or through infection, or a combination of the two,” he added. “The toy is even more level.”

Leave a Reply

Your email address will not be published.